A major goal of the Center/Clark is to establish an interlocking network of scholars devoted to the study of the seventeenth and eighteenth centuries. In pursuit of this aim, the Center/Clark has established cooperative agreements with a number of institutions. The agreements vary, but all stress the aim to foster interdisciplinary and comparative research and to enable scholars from different areas and countries to share their findings. Agreements of cooperation have been reached with the Centro Interdipartimentale di Studi su Descartes e il Seicento in Lecce, Italy; the Scuola Normale Superiore in Pisa; the Swedish Collegium for Advanced Studies in the Social Sciences in Uppsala; the Università di Bologna; and the University of Warwick in Coventary. Other cooperative agreements are being explored.

In addition, the Center/Clark works very closely with both the American Society for Eighteenth-Century Studies (ASECS) and the International Society for Eighteenth-Century Studies (ISECS). The Clark Library is the repository for the ASECS archives. In academic year 2000-2001, the Center/Clark hosted and helped to organize the ISECS International Seminar on the Eighteenth Century. This seminar, formerly known as the East/West Seminar, annually brings together outstanding junior scholars from across the world to participate in an intensive weeklong discussion of a specific eighteenth-century theme. It is expected that the Center/Clark will remain one of the permanent American sites for this seminar.

The Quadrennial Congress of ISECS, held at UCLA in the first week of August 2003, was hosted by the Center and the Clark together with ASECS, whose annual meeting was combined with the ISECS Congress. The event was organized and coordinated by Peter Reill, Center/Clark Director, and by John Sandbrook, Assistant Provost of UCLA's College of Letters and Science. A select committee of scholars from the region and the nation, representing all the major disciplines concerned with the era, assisted in the planning and organizing.